EHEN

resources

9 resources

  • ATHLETE

    Advancing Tools for Human Early Lifecourse Exposome Research and Translation
    Children are particularly vulnerable to environmental hazards. The ATHLETE project will measure a wide range of environmental exposures (urban, chemical, lifestyle and social risk factors) during pregnancy, childhood, and adolescence. The project will then link this “early-life exposome” to children’s biological responses and cardiometabolic, respiratory, and mental health. The results will help us to better understand and prevent health damage from environmental agents from the earliest parts of the life course onward.

  • EPHOR

    EPHOR
    The EPHOR project will lay the groundwork for evidence-based and cost-effective prevention to improve health at work by developing a working-life exposome toolbox. The total burden of disease caused by occupational exposure is estimated at 5-7%, similar to the burden resulting from urban air pollution or obesity. Given the associated societal and economic pressure, a healthy work environment is an important goal for government and industry. Current risk reduction policies and strategies are informed by existing scientific evidence. However, this evidence is limited due to the challenges of studying the complex relationship between exposure at and outside of work, and health. We define the working-life exposome as all occupational and related non-occupational exposures (e.g. lifestyle, behaviour) throughout the course of life. Taking a working-life exposome approach will mean a great step for occupational health science. It will help address the current limitations and challenges by providing better insights into the relationships between exposure at work and disease at different life stages. EPHOR will develop methods and tools to characterise the working-life exposome. By applying these to both existing data and for collection of new data, we will enhance our knowledge of the working-life exposome. EPHOR’s tools, methods and knowledge will be made available in a toolbox to scientists, policy makers and occupational health practitioners.

  • Equal-Life

    Equal-Life
    The Equal-Life project will develop and test combined exposure data using a new approach to multi-modal exposures and their impact on children’s mental health and development. A combination of birth cohort data with new data sources will provide new insights into aspects of physical and social exposures. It will do this for a range of scales and time frames while accounting for the distribution of exposures in social groups based on gender, ethnicity and social vulnerability.

  • EXIMIOUS

    Mapping exposure-induced immune effects: connecting the exposome and the immunome
    The EXIMIOUS consortium—gathering experts in immunology, toxicology, clinical medicine, environmental hygiene, epidemiology, bioinformatics and sensor development—will bring about a new way of assessing the human exposome by linking innovative ways of characterizing and quantifying multiple and combined environmental exposures (exposomics) with high-dimensional immunophenotyping and profiling platforms to map early immune effects induced by these exposures (immunomics). In several cohorts—covering the entire lifespan, including prenatal life—we will map exposome, immune system (immunome), and other omics and clinical and socio-economic data, using two main methodologies—one starting from the exposome, the other starting from health effects—that ‘meet in the middle’. We will use novel bioinformatics tools, based on systems immunology and machine learning to integrate and analyse these datasets and to construct ‘immune fingerprints’ that reflect a person’s lifetime exposome and identify ‘immune fingerprints’ that are early signs of poor health and predictors of disease at an individual level. We will build a multifaceted toolbox for researchers, policy makers, clinicians and the general public containing the exposome/immunome tools developed during the project to help assess the impact of the exposome on the immune system at the level of individuals and populations. This will allow policy makers to design preventive policies to reduce healthcare and socioeconomic costs.

  • EXPANSE

    EXPANSE
    The Urban Exposome is the complex mixture of social and environmental factors in the urban environment that collectively have an impact on health. Currently, slightly over 70% of Europe’s population lives in an urban environment. This percentage is expected to exceed 80% by 2030. It is therefore crucial that European urban areas provide a healthy living environment. The EXPANSE project addresses one of the most pertinent questions for urban planners, policy makers, and inhabitants in Europe: “How to maximize health in a modern urban environment?”

  • HEAP

    Human exposome assessment platform
    The HEAP project will provide an informatics platform for handling and analysing large amounts of data on environmental exposures and their health effects. The platform will be populated with data from large-population-based cohorts, analysed with high-throughput technologies such as analysis of microbes with metagenomics and analysis of the effects of the environment on the genome (epigenomics). The HEAP platform will also analyse data from large and population-based cohorts on the health effects of purchased products using consumer receipts, and data from volunteer cohorts that carry sensors for continuous monitoring of environmental exposures.

  • HEDIMED

    Human exposomic determinants of immune mediated diseases
    The HEDIMED project comprises 22 partners from 12 different countries, and aims to identify the exposomic determinants that are driving the rapid increase of immune-mediated diseases (IMDs) such as type 1 diabetes, celiac disease, allergies and asthma. The project will use data and samples from large clinical cohorts and trials from countries with both high and low IMD incidence. Exposomic disease determinants and the underlying biological pathways will be identified using advanced omics, multiplex and data-mining technologies.

  • LongITools

    LongITools Health & Environment Dynamics
    LongITools is a European research project studying the interactions between the environment, lifestyle and health in determining the risks of chronic cardiovascular and metabolic diseases.

  • REMEDIA

    Impact of exposome on the course of lung diseases
    The objective of the REMEDIA project is to better understand the contribution of the exposome to two untreatable respiratory diseases: chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). Starting from the study of patient cohorts throughout life, REMEDIA will develop a toolbox to help identify modifiable risk factors and therefore better predict disease risk. These insights will allow preventive actions to be developed and implemented.

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