LifeCycle

collections

Data & sample collections

19 collections

  • ALSPAC

    Avon Longitudinal Study of Parents and Children
    Based at the University of Bristol, the Avon Longitudinal Study of Parents and Children (ALSPAC), also known as Children of the 90s, is a world-leading birth cohort study. Between April 1991 and December 1992 we recruited more than 14,000 pregnant women into the study and these women (some of whom had two pregnancies or multiple births during the recruitment period), the children arising from the pregnancy, and their partners have been followed up intensively over two decades. We are the most detailed study of its kind in the world and we provide the international research community with a rich resource for the study of the environmental and genetic factors that affect a person’s health and development. Through our research we aim to inform policy and practices that will provide a better life for future generations.

  • BIB

    Born in Bradford
    Born in Bradford (BiB) started in 2007 as a response to the poor health outcomes for children in Bradford. Pregnant women were recruited when they attended the Bradford Royal Infirmary for their routine maternity care. Participants were asked to complete a questionnaire about different aspects of their lives including demographics information, physical and mental health and socio-economic information. Between 2007 and 2011, 12,453 pregnant women were recruited and 3,353 of their partners. Participants also gave permission for routine data linkage for themselves and their children. The BiB cohort is split between approximately 50% South Asian and 50% non-South Asian participants. BiB has completed a number of sub-sample studies including BiB1000, which focused on exploring ethnic variation and risk factors of childhood obesity. Data collection included questionnaires with parents when the children were between 6 and 36 months at 6 monthly intervals.The ALLIN and MeDALL studies focused on the relationships between childhood allergies and infections. Data collection for these studies were done via a questionnaire and, for the MeDALL study, children were asked to have a skin allergy test. Since 2016, BiB have undertaken a full cohort follow-up compromising of home visits for data collection through questionnaires, school visits where children carried out cognitive assessments, and a child measurement programme where children were weighed and measured, had their activity levels measured, and were asked to give a blood sample. From the findings of these studies, BiB have developed a range of additional research projects such as evaluating and developing new interventions to improve health; for example, focusing on reducing childhood obesity, increasing physical activity, improving oral health and improving mental wellbeing. BiB have gone beyond functioning as an observational birth cohort and are actively trying to build and strengthen local research capacity and translate evidence to practice.

  • CHOP

    Childhood Obesity Programme
    The European Childhood Obesity Project (CHOP) was a one-year multicentre double-blind randomized controlled intervention trial including 1678 children (registered at ClinicalTrials.gov: NCT00338689). The aim was to test whether feeding infant formula, which differ in their level of milk proteins, can influence infant growth and the risk of later childhood obesity ('early protein hypothesis'). Healthy singleton term infants born between 1st October 2002 and 31st July 2004 were recruited in five European countries (Belgium, Germany, Italy, Poland, Spain) during their 8 weeks of life. They were randomized to cow-milk based formula with either higher or lower protein-content. Additionally a reference group of breastfed children was included. After the intervention, children were prospectively followed up until the age of 11 years.

  • DNBC

    The Danish National Birth Cohort
    The Danish National Birth Cohort (DNBC) was established to investigate the causal link between exposures in early life and disease later on and the possibilites for disease prevention. Initial data collection information was collected by computer-assisted telephone interviews with the women twice during pregnancy and when their children were six and 18 months old. Further data collections were conducted when the children were 7, 11 and 18 years old. For more details, please visit the DNBC homepage.

  • EDEN

    Study on the pre and early postnatal determinants of child health and development
    The EDEN study is a French bicentric generalist cohort study (Heude et al. IJE 2016). Pregnant women were invited to participate during their prenatal visit, before the 24th week of amenorrhea, in the obstetrics and gynecology departments of the Poitiers and Nancy university hospitals. Recruitment took place from February 2003 to January 2006. The exclusion criteria were: twin pregnancy, diagnosis of insulin-dependent diabetes, inability to speak and read French, intention to move from the region within three years of inclusion . Among the women invited, 53% agreed to participate (n = 2,002). Detailed information on phenotypes and exposures were collected through questionnaires from pregnancy until 8 years and through clinical examinations of the mother (at 24 weeks of amenorrhoea, at delivery and 5–6 years after delivery) and the child (at birth and 1, 3 and 5–6 years, including cognitive assessments at 3 and 5–6 years). At 5–6 years, 1255 children were still followed up.

  • ELFE

    Etude Longitudinale Française depuis l'Enfance" (French longitudinal study of children)
    ELFE is the first French national birth cohort. Its objective is to study determinants of the development, health and socialization of children from birth to adulthood through a multidisciplinary approach. A total of 18 329 children were recruited at birth in a random sample of maternity units in metropolitan France during 25 selected days of 2011 spread over the year. Participation rates at the age 2-month, 1- and 2-year and 3.5-year parental interviews were 92%, 86%, 82% and 80%, respectively, of contacted participants. The ELFE has an open-data policy after an 18-month exclusivity period following each release of new data. The data-access policy, study protocols, questionnaires and data catalogue can be found online: [https://www.ELFE-france.fr/en/].

  • GECKO Drenthe

    The Groningen Expert Center for Kids with Obesity
    The GECKO Drenthe study is a Dutch population-based birth cohort including children born in 2006 and 2007, designed to study the determinants and development of childhood overweight. Monitoring of the children started from the last trimester of the pregnancy and is still ongoing.

  • GenR

    The Generation R Study
    The Generation R Study is a population-based prospective cohort study from fetal life until adulthood and is conducted in Rotterdam, the second largest city in the Netherlands. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health from fetal life, childhood and young adulthood. This multidisciplinary study focuses on several health outcomes including behaviour and cognition, body composition, eye development, growth, hearing, heart and vascular development, infectious disease and immunity, oral health and facial growth, respiratory health, allergy and skin disorders of children and their parents. Main exposures of interest include environmental, endocrine, genomic (genetic, epigenetic, microbiome), lifestyle related, nutritional and socio-demographic determinants. The Generation R study enrolled 9,153 mothers with a delivery date from April 2002 until January 2006, who participated with a total of 9,778 pregnancies in the study from which 9,901 children were expected to be born; the mothers gave birth to 9,749 live born children.

  • GenR Next

    Generation R Next
    The Generation R Next Study is a population-based cohort study from preconception onwards. In total, about 3600 women are being included in the period 2017-2021. Of all included couples, about 30% is included during the preconception, about 60% during the first trimester of pregnancy and about 10% in the third trimester of pregnancy.

  • HBCS

    Helsinki Birth Cohort Study

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