The EPHOR project will lay the groundwork for evidence-based and cost-effective prevention to improve health at work by developing a working-life exposome toolbox. The total burden of disease caused by occupational exposure is estimated at 5-7%, similar to the burden resulting from urban air pollution or obesity. Given the associated societal and economic pressure, a healthy work environment is an important goal for government and industry. Current risk reduction policies and strategies are informed by existing scientific evidence. However, this evidence is limited due to the challenges of studying the complex relationship between exposure at and outside of work, and health. We define the working-life exposome as all occupational and related non-occupational exposures (e.g. lifestyle, behaviour) throughout the course of life. Taking a working-life exposome approach will mean a great step for occupational health science. It will help address the current limitations and challenges by providing better insights into the relationships between exposure at work and disease at different life stages. EPHOR will develop methods and tools to characterise the working-life exposome. By applying these to both existing data and for collection of new data, we will enhance our knowledge of the working-life exposome. EPHOR’s tools, methods and knowledge will be made available in a toolbox to scientists, policy makers and occupational health practitioners.
WebsiteNetwork detailsCONSTANCES
Cohorte des Consultants des Centres d’Examens de Santé
Description
The CONSTANCES cohort was established in late 2012 and was designed as a randomly selected representative sample of French adults aged 18-69 years at inception. 200,000 subjects will be included over a five-year period.
The CONSTANCES general-purpose cohort is intended to serve as an epidemiological research infrastructure accessible to the epidemiologic research community with a focus on occupational and social factors, and on chronic diseases and aging. CONSTANCES will also provide useful public health information to the public health authorities since it was designed as a large representative sample of the general French adult population. CONSTANCES is designed as a randomly selected representative sample of French adults aged 18–69 years at inception; 200,000 subjects will be included over a five-year period. At inclusion, the selected subjects are invited to complete questionnaires and to attend a Health Screening Center (HSC) for a comprehensive health examination. A biobank will be set up. The follow-up includes a yearly self-administered questionnaire, and a periodic visit to an HSC. Social and health data are collected from the French national databases. Data collected for participants include social and demographic characteristics, socioeconomic status, life events, behaviors, and occupational factors. The health data cover a wide spectrum: self-reported health scales, reported prevalent and incident diseases, long-term chronic diseases and hospitalizations, sick-leaves, handicaps, limitations, disabilities and injuries, healthcare utilization and services provided, and causes of death. To take into account non-participation at inclusion and attrition throughout the longitudinal follow-up, a cohort of non-participants was set up and will be followed through the same national databases as participants. Inclusion begun at the end of 2012 and more than 82,000 were already included by September 2015. A public call for nested research projects was launched.
General Design
- Type
- Cohort study
- Cohort type
- Population cohort
- Data collection type
- Retrospective, Prospective
- Design
- Longitudinal
- Start/End data collection
- 2012 until 2021
- Design paper
- The French CONSTANCES population-based cohort: design, inclusion and follow-up.
Population
- Continents
- Europe
- Countries
- France
- Number of participants
- 220000
- Population age groups
- Adult (18+ years)
Organisations
Lead organisations
- Inserm (INSERM)Francehttps://www.inserm.fr
Contributors
Available Data & Samples
Data categories
- Omics
- Genomics
Areas of information
- Socio-demographic and economic characteristics
- Socio-economic capital
- Age/birthdate
- Sex/gender
- Ethnicity, race and religion
- Labour force and retirement
- Job history
- Lifestyle and behaviours
- Tobacco
- Alcohol
- Drugs
- Nutrition
- Physical activity
- Sleep
- Cognition, personality and psychological measures and assessments
- Psychological distress and emotions
- Physical environment
- Geocodes for residential address
- Workplace characteristics
- Air pollution (outdoor)
- Air pollution (indoor)
- Noise, traffic, or light
- Meteorology
Data dictionaries
Tables
Tables and their description
| Name | Description | |
|---|---|---|
No results for current selection |
Variables
Variables and their description
| Variable | Table | |
|---|---|---|
No results for current selection |
Collection events
List of collection events defined for this resource
| Name | Description | Participants | Start end year | |
|---|---|---|---|---|
No results for current selection |
Networks
Part of networks