Welcome to the catalogue of UNCAN-Connect: Decentralised Collaborative Network for Advancing Cancer Research and Innovation. Europe represents a quarter of the world’s cancer cases, with cancer being the second leading cause of death in the region. Without action, cancer deaths in the EU could rise by over 24 % by 2035. The EU-funded UNCAN-Connect project will establish a decentralised collaborative network for cancer research, focusing on paediatric cancers, lymphoid malignancies, pancreatic, ovarian, lung, and prostate cancers. The initiative will create a governance framework and engage various stakeholders, including researchers, SMEs, and citizens, while facilitating data storage, access, and sharing across member states. This effort is part of the EU Cancer Mission’s Understanding Cluster, launched in 2022..